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Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer
Journal of Clinical Oncology · 2000 · Vol. 18(16) · pp. 2938–2947
Aimery de Gramont✉Arié FigerMichel SeymourM. HomerinAbdel HmissiJim CassidyC. BoniH. Cortés-FunesAndrés CervantesGilles FreyerD. PapamichaelN Le BailChristophe LouvetDaniel HendlerFilippo de Braud(Fondazione IRCCS Istituto Nazionale dei Tumori)C. WilsonF. MorvanAndrea Bonetti
Abstract
The LV5FU2-oxaliplatin combination seems beneficial as first-line therapy in advanced colorectal cancer, demonstrating a prolonged progression-free survival with acceptable tolerability and maintenance of QoL.
Colorectal Cancer Treatments and StudiesCancer Treatment and PharmacologyGastric Cancer Management and OutcomesMedicineOxaliplatinFluorouracilBolus (digestion)RegimenNeutropeniaInternal medicineGastroenterologyColorectal cancerPhases of clinical research
MeSH terms
OxaliplatinAdenocarcinomaAdolescentAdultAgedAntineoplastic Combined Chemotherapy ProtocolsLeucovorinDiarrheaFemaleFluorouracilHumansMaleMiddle AgedNeutropeniaOrganoplatinum Compounds
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