articleTop 1% cited

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

Nature Immunology · 2004 · Vol. 5(2) · pp. 190–198

Eicke Latz✉Annett Schoenemeyer(University of Massachusetts Chan Medical School)Alberto Visintin(University of Massachusetts Chan Medical School)Katherine A. Fitzgerald(University of Massachusetts Chan Medical School)Brian G. Monks(University of Massachusetts Chan Medical School)Cathrine Knetter(Norwegian University of Science and Technology)Egil Lien(University of Massachusetts Chan Medical School)Nadra Nilsen(Norwegian University of Science and Technology)Terje Espevik(Norwegian University of Science and Technology)Douglas T. Golenbock(University of Massachusetts Chan Medical School)

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Immune Response and Inflammation Immunotherapy and Immune Responses RNA Interference and Gene DeliveryTLR9Toll-Like Receptor 9CpG siteCell biologyEndoplasmic reticulumDNAEndosomeBiologyChemistryGene

MeSH terms

AnimalsAntigens, DifferentiationBiological Transport, ActiveCell LineDendritic CellsDNA-Binding ProteinsEndoplasmic ReticulumHumansLuminescent ProteinsLysosomesMembrane GlycoproteinsMice, Inbred C57BLReceptors, Cell SurfaceReceptors, ImmunologicRecombinant Fusion Proteins

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Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner