reviewTop 1% cited
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Journal of Pharmacology and Experimental Therapeutics · 2006 · Vol. 320(1) · pp. 1–13
Jonathan D. Urban✉William P. Clarke(The University of Texas Health Science Center at San Antonio)Mark von Zastrow(University of California, San Francisco)David E. Nichols(Purdue University West Lafayette)Brian K. Kobilka(Stanford University)Harel Weinstein(Cornell University)Jonathan A. Javitch(Columbia University)Bryan L. RothArthur Christopoulos(Australian Regenerative Medicine Institute)Patrick M. Sexton(Australian Regenerative Medicine Institute)Keith J. Miller(Bristol-Myers Squibb (Germany))Michael Spedding(Servier (France))Richard B. Mailman
Receptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyPharmacogenetics and Drug MetabolismFunctional selectivityIntrinsic activityReceptorSignal transductionMechanism (biology)AgonistMolecular PharmacologyBiologyNeurosciencePartial agonist
MeSH terms
AnimalsHumansLigandsProtein ConformationReceptors, Cell SurfaceSignal TransductionReceptors, Dopamine D1Receptors, Dopamine D2Receptors, Opioid, muReceptors, VasopressinReceptors, Adrenergic, beta-2Receptors, G-Protein-Coupled
Funding
- U.S. Food and Drug Administration
Citations
1,103
FWCI
31.76
field-weighted impact
References
120
Percentile
100%
vs. same field & year
Citations per year
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References
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Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology
Neuropsychopharmacology · 2003 · 967 citations
Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus
Molecular Pharmacology · 1998 · 512 citations
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Functional Selectivity and Classical Concepts of Quantitative Pharmacology
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