articleTop 10% cited

Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

Molecular Pharmacology · 1998 · Vol. 54(1) · pp. 94–104

Kelly A. Berg✉(Icahn School of Medicine at Mount Sinai)Saul Maayani(City University of New York)Joseph Goldfarb(Icahn School of Medicine at Mount Sinai)Clare Scaramellini(The University of Texas Health Science Center at San Antonio)Paul Leff(Icahn School of Medicine at Mount Sinai)William P. Clarke(City University of New York)

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Receptor Mechanisms and Signaling Neurotransmitter Receptor Influence on Behavior Neuropeptides and Animal PhysiologyAgonistFunctional selectivityReceptorSignal transductionPharmacologyChemistryPhospholipase CIntrinsic activityBiologyCell biology

MeSH terms

AnimalsBufoteninCricetinaeHumansLysergic Acid DiethylamideModels, ChemicalNeuropeptidesType C PhospholipasesPhospholipases APiperazinesQuipazineReceptors, SerotoninSerotonin AntagonistsSignal TransductionCHO Cells

Citations

512

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7.20

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98%

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology