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A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Cancer Cell · 2007 · Vol. 11(1) · pp. 37–51

Sébastien Bonnet(University of Alberta)Stephen L. Archer(University of Alberta)Joan Allalunis‐Turner(University of Alberta)Alois Haromy(University of Alberta)Christian Beaulieu(University of Alberta)Richard B. Thompson(University of Alberta)Christopher T. Lee(University of Alberta)Gary D. Lopaschuk(University of Alberta)Lakshmi Puttagunta(University of Alberta)Sandra Breuils Bonnet(University of Alberta)Gwyneth Harry(University of Alberta)Kyoko Hashimoto(University of Alberta)Christopher J. Porter(Ontario Genomics)Miguel A. Andrade‐Navarro(University of Ottawa)Bernard Thébaud(University of Alberta)Evangelos D. Michelakis✉(University of Alberta)

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Mitochondrial Function and Pathology Ion channel regulation and function ATP Synthase and ATPases ResearchApoptosisCancer cellMitochondrionCell biologyCancer researchGlycolysisAnaerobic glycolysisBiologyInner mitochondrial membraneChemistry

MeSH terms

Pyruvate Dehydrogenase Acetyl-Transferring KinaseAnimalsDichloroacetic AcidHumansMitochondriaNeoplasmsProtein KinasesRats, NudeImmunoblottingPotassium ChannelsApoptosisProtein Serine-Threonine KinasesPatch-Clamp TechniquesMicroscopy, ConfocalReverse Transcriptase Polymerase Chain Reaction