reviewTop 1% cited

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1

Neurobiology of Aging · 2002 · Vol. 23(5) · pp. 655–664

D ALLANBUTTERFIELD✉(University of Kentucky)Alessandra Castegna(University of Kentucky)Christopher M. Lauderback(University of Kentucky)James Drake(University of Kentucky)

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Alzheimer's disease research and treatments Antioxidant Activity and Oxidative Stress Retinoids in leukemia and cellular processesLipid peroxidationChemistryOxidative stressBiochemistry4-HydroxynonenalNeurotoxicityGlutamate receptorAmyloid betaPeptideToxicity

MeSH terms

AgedAlzheimer DiseaseHumansNeuronsLipid PeroxidationAmyloid beta-PeptidesCell Death

Citations

713

FWCI

18.59

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References

103

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100%

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References

Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures

Neurobiology of Aging · 2001 · 445 citations

Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease

Experimental Neurology · 1998 · 511 citations

Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

Neurobiology of Aging · 1998 · 677 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

Journal of Neurochemistry · 1997 · 775 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

Free Radical Biology and Medicine · 1997 · 2,368 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

Journal of Neurochemistry · 1995 · 776 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

Free Radical Biology and Medicine · 1991 · 6,615 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

Journal of Neurochemistry · 1997 · 1,009 citations

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