articleTop 10% cited

Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures

Neurobiology of Aging · 2001 · Vol. 22(2) · pp. 187–194

Mark A. Lovell(University of Kentucky)Chengsong Xie(University of Kentucky)William R. Markesbery✉(University of Kentucky)

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Antioxidant Activity and Oxidative Stress Free Radicals and Antioxidants Phytochemicals and Antioxidant ActivitiesAcroleinNeurotoxicityLipid peroxidationPathogenesisHippocampal formationOxidative stressChemistryHippocampusInternal medicineEndocrinology

MeSH terms

AcroleinAgedAged, 80 and overAlzheimer DiseaseAnimalsCalciumCells, CulturedChromatography, High Pressure LiquidDose-Response Relationship, DrugFemaleFree RadicalsHippocampusHumansMaleNeurons

Funding

National Institutes of Health

Citations

445

FWCI

7.37

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

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References

Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

Neurobiology of Aging · 1998 · 677 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

Journal of Neurochemistry · 1997 · 775 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

Annals of Neurology · 1994 · 1,030 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

Journal of Neurochemistry · 1995 · 776 citations

Neuropathological stageing of Alzheimer-related changes

Acta Neuropathologica · 1991 · 16,076 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

Free Radical Biology and Medicine · 1991 · 6,615 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

Journal of Neurochemistry · 1997 · 1,009 citations

The Clinical Diagnosis of Alzheimer's Disease

Archives of Neurology · 1987 · 1,380 citations

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