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Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

Acta Neuropathologica · 2015 · Vol. 129(2) · pp. 183–206

Kirsten L. Viola✉(Northwestern University)William L. Klein(Northwestern University)

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Alzheimer's disease research and treatments Neuroscience and Neuropharmacology Research Cholinesterase and Neurodegenerative DiseasesNeuropathologyHyperphosphorylationNeurosciencePathogenesisDementiaAlzheimer's diseaseAmyloid (mycology)BiologyDiseaseMedicine

MeSH terms

Alzheimer DiseaseAnimalsHumansNeuronsAmyloid beta-Peptides

Funding

National Institutes of Health

Citations

606

FWCI

30.73

field-weighted impact

References

198

Percentile

100%

vs. same field & year

Citations per year

Cited by

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Acta Neuropathologica · 2016 · 787 citations

References

High-Level Neuronal Expression of Aβ<sub>1–42</sub>in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Journal of Neuroscience · 2000 · 1,860 citations

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

Trends in Neurosciences · 2001 · 994 citations

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

Neurobiology of Aging · 2007 · 417 citations

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

Nature Neuroscience · 2012 · 1,926 citations

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

Nature Neuroscience · 2004 · 1,667 citations

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1

Neurobiology of Aging · 2002 · 713 citations

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

Archives of Neurology · 2011 · 1,217 citations

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

Journal of Biological Chemistry · 2004 · 2,288 citations

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