article Open AccessTop 1% cited
The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
The EMBO Journal · 1999 · Vol. 18(6) · pp. 1571–1583
Mangeng Cheng✉(St. Jude Children's Research Hospital)
Cancer-related Molecular PathwaysUbiquitin and proteasome pathwaysCancer, Hypoxia, and MetabolismCyclin-dependent kinaseBiologyKinaseProtein-Serine-Threonine KinasesCell biologyCyclinPhosphorylationCancer researchMolecular biologyBiochemistry
MeSH terms
AnimalsCell LineCells, CulturedEmbryo, MammalianEnzyme InhibitorsFibroblastsHumansKineticsMicrotubule-Associated ProteinsProto-Oncogene ProteinsRecombinant Fusion ProteinsTransfectionCyclinsMice, KnockoutCell Cycle Proteins
Funding
- National Institutes of Health
Citations
1,141
FWCI
38.82
field-weighted impact
References
87
Percentile
100%
vs. same field & year
Citations per year
Cited by
The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
Cancers · 2019 · 303 citations
The RB and p53 pathways in cancer
Cancer Cell · 2002 · 1,658 citations
Inhibition of Histone Deacetylase Activity by Butyrate
Journal of Nutrition · 2003 · 1,412 citations
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition
Oncogene · 2007 · 1,098 citations
Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM
Cell Death and Differentiation · 2017 · 655 citations
CDK inhibitors: positive and negative regulators of G1-phase progression
Genes & Development · 1999 · 6,077 citations
Regulation of the Cdk inhibitor p27 and its deregulation in cancer
Journal of Cellular Physiology · 2000 · 672 citations
References
D-type cyclin-dependent kinase activity in mammalian cells.
Molecular and Cellular Biology · 1994 · 1,055 citations
High-efficiency transformation of mammalian cells by plasmid DNA.
Molecular and Cellular Biology · 1987 · 5,334 citations
Phosphoinositide 3-kinases: A conserved family of signal transducers
Trends in Biochemical Sciences · 1997 · 945 citations
The retinoblastoma protein and cell cycle control
Cell · 1995 · 4,876 citations
Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes & Development · 1995 · 3,256 citations
WAF1, a potential mediator of p53 tumor suppression
Cell · 1993 · 8,369 citations
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
Cell · 1993 · 5,653 citations
Cyclin D1 is a nuclear protein required for cell cycle progression in G1.
Genes & Development · 1993 · 1,627 citations
Related articles
Targeting Cyclin-Dependent Kinases in Human Cancers: From Small Molecules to Peptide Inhibitors
Cancers · 2015 · 340 citations
The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
The EMBO Journal · 1999 · 1,141 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
