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The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

The EMBO Journal · 1999 · Vol. 18(6) · pp. 1571–1583
Mangeng Cheng
Cancer-related Molecular PathwaysUbiquitin and proteasome pathwaysCancer, Hypoxia, and MetabolismCyclin-dependent kinaseBiologyKinaseProtein-Serine-Threonine KinasesCell biologyCyclinPhosphorylationCancer researchMolecular biologyBiochemistry

MeSH terms

AnimalsCell LineCells, CulturedEmbryo, MammalianEnzyme InhibitorsFibroblastsHumansKineticsMicrotubule-Associated ProteinsProto-Oncogene ProteinsRecombinant Fusion ProteinsTransfectionCyclinsMice, KnockoutCell Cycle Proteins

Funding

  • National Institutes of Health
Citations
1,141
FWCI
38.82
field-weighted impact
References
87
Percentile
100%
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Citations per year
References
D-type cyclin-dependent kinase activity in mammalian cells.
Molecular and Cellular Biology · 1994 · 1,055 citations
High-efficiency transformation of mammalian cells by plasmid DNA.
Molecular and Cellular Biology · 1987 · 5,334 citations
Phosphoinositide 3-kinases: A conserved family of signal transducers
Trends in Biochemical Sciences · 1997 · 945 citations
Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes & Development · 1995 · 3,256 citations
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