review Open AccessTop 1% cited
Protein aggregation: Pathways, induction factors and analysis
Journal of Pharmaceutical Sciences · 2008 · Vol. 98(9) · pp. 2909–2934
Hanns‐Christian Mahler✉(Roche (Switzerland))Wolfgang Frieß(Ludwig-Maximilians-Universität München)Ulla Grauschopf(Roche (Switzerland))Sylvia Kiese(Roche (Switzerland))
Protein purification and stabilityViral Infectious Diseases and Gene Expression in InsectsMonoclonal and Polyclonal Antibodies ResearchChemistryPathway analysisBiochemistry
MeSH terms
Chemistry Techniques, AnalyticalProteinsProtein Stability
Citations
879
FWCI
12.69
field-weighted impact
References
222
Percentile
99%
vs. same field & year
Citations per year
Cited by
Aggregates in monoclonal antibody manufacturing processes
Biotechnology and Bioengineering · 2011 · 473 citations
Immunogenicity of Therapeutic Protein Aggregates
Journal of Pharmaceutical Sciences · 2016 · 510 citations
Theory and practice of size exclusion chromatography for the analysis of protein aggregates
Journal of Pharmaceutical and Biomedical Analysis · 2014 · 311 citations
Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates
Pharmaceutical Research · 2010 · 1,792 citations
Stability of Protein Pharmaceuticals: An Update
Pharmaceutical Research · 2010 · 1,076 citations
References
Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation
Pharmaceutical Research · 2003 · 1,362 citations
Singlet oxygen-mediated damage to proteins and its consequences
Biochemical and Biophysical Research Communications · 2003 · 967 citations
The stabilization of proteins by osmolytes
Biophysical Journal · 1985 · 1,018 citations
Tricine–SDS-PAGE
Nature Protocols · 2006 · 2,491 citations
Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels
Biochemical and Biophysical Research Communications · 1967 · 3,778 citations
Polysorbates 20 and 80 Used in the Formulation of Protein Biotherapeutics: Structure and Degradation Pathways
Journal of Pharmaceutical Sciences · 2007 · 774 citations
Antibody Structure, Instability, and Formulation
Journal of Pharmaceutical Sciences · 2006 · 923 citations
ON THE BINDING OF CONGO RED BY AMYLOID
Journal of Histochemistry & Cytochemistry · 1962 · 1,136 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.