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Theory and practice of size exclusion chromatography for the analysis of protein aggregates

Journal of Pharmaceutical and Biomedical Analysis · 2014 · Vol. 101 · pp. 161–173

Szabolcs Fekete✉Alain Beck(Center of Immunology Pierre Fabre)Jean‐Luc Veuthey(University of Lausanne)Davy Guillarme(University of Geneva)

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Protein purification and stability Analytical Chemistry and Chromatography Monoclonal and Polyclonal Antibodies ResearchChemistrySize-exclusion chromatographyCharacterization (materials science)Mass spectrometryRefractometryChromatographyResolution (logic)Particle sizeAnalytical Chemistry (journal)Refractive index

MeSH terms

Chromatography, GelIndicators and ReagentsParticle SizeProteinsRefractometryProtein Aggregates

Citations

311

FWCI

11.67

field-weighted impact

References

105

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99%

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Cited by

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References

Aggregates in monoclonal antibody manufacturing processes

Biotechnology and Bioengineering · 2011 · 473 citations

Instability, stabilization, and formulation of liquid protein pharmaceuticals

International Journal of Pharmaceutics · 1999 · 1,052 citations

Protein aggregation and its inhibition in biopharmaceutics

International Journal of Pharmaceutics · 2005 · 966 citations

Protein aggregation: Pathways, induction factors and analysis

Journal of Pharmaceutical Sciences · 2008 · 879 citations

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