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Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Diabetes · 2008 · Vol. 58(1) · pp. 250–259
Jing Xu✉(Amgen (United States))David J. Lloyd(Amgen (United States))Clarence Hale(Amgen (United States))Shanaka Stanislaus(Amgen (United States))Michelle Chen(Amgen (United States))Glenn Sivits(Amgen (United States))Steven Vonderfecht(Amgen (United States))Randy Hecht(Amgen (United States))Yue‐Sheng Li(Amgen (United States))Richard Lindberg(Amgen (United States))Jinlong Chen(Amgen (United States))Dae Young Jung(Pennsylvania State University)Zhiyou Zhang(Pennsylvania State University)Hwi-Jin Ko(Pennsylvania State University)Jason K. Kim(Pennsylvania State University)Murielle M. Véniant(Amgen (United States))
Abstract
FGF21 corrects multiple metabolic disorders in DIO mice and has the potential to become a powerful therapeutic to treat hepatic steatosis, obesity, and type 2 diabetes.
Fibroblast Growth Factor ResearchKruppel-like factors researchEpigenetics and DNA MethylationFGF21EndocrinologyInternal medicineSteatosisLipid metabolismInsulin resistanceTriglycerideFatty liverType 2 diabetesInsulin
MeSH terms
MiceAnimalsBlood GlucoseBody WeightCalorimetryDietary FatsEnergy MetabolismFatty LiverFibroblast Growth FactorsGlucokinaseInsulinInsulin ResistanceLipidsMaleMice, Inbred C57BL
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References
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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
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