review Open AccessTop 1% cited

Brown and beige fat: development, function and therapeutic potential

Nature Medicine · 2013 · Vol. 19(10) · pp. 1252–1263

Matthew Harms✉(University of Pennsylvania)Patrick Seale(University of Pennsylvania)

Adipose Tissue and Metabolism Adipokines, Inflammation, and Metabolic Diseases Exercise and Physiological ResponsesAdipose tissueAdipocyteThermogenesisBiologyBrown adipose tissueObesityDiseaseWhite adipose tissueEndocrinologyInternal medicine

MeSH terms

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAnimalsAdipose Tissue, BrownHumansMetabolic DiseasesSympathetic Nervous SystemTranscription FactorsAdipocytesMice

Funding

National Institutes of Health

Citations

2,280

FWCI

82.81

field-weighted impact

References

195

Percentile

100%

vs. same field & year

Citations per year

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References

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

PLoS Biology · 2005 · 941 citations

Transcriptional Control of Brown Fat Determination by PRDM16

Cell Metabolism · 2007 · 1,155 citations

FGF-21 as a novel metabolic regulator

Journal of Clinical Investigation · 2005 · 2,064 citations

Adipocyte differentiation from the inside out

Nature Reviews Molecular Cell Biology · 2006 · 2,574 citations

Unexpected evidence for active brown adipose tissue in adult humans

American Journal of Physiology-Endocrinology and Metabolism · 2007 · 1,783 citations

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

American Journal of Physiology-Endocrinology and Metabolism · 2010 · 749 citations

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

Diabetes · 2008 · 1,133 citations

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Endocrinology · 2008 · 1,010 citations

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