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TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Immunity · 2006 · Vol. 24(2) · pp. 179–189
Marc VeldhoenRichard J. HockingChristopher J. AtkinsRichard M. Locksley(Howard Hughes Medical Institute)Brigitta Stockinger✉
T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunodeficiency and Autoimmune DisordersBiologyIL-2 receptorCell biologyCytokineProinflammatory cytokineTLR9ImmunologyCellular differentiationInterleukin 21CD40
MeSH terms
AnimalsCell DifferentiationCells, CulturedDendritic CellsMembrane GlycoproteinsMice, Inbred C57BLMice, TransgenicT-LymphocytesCD4-Positive T-LymphocytesLymphocyte SubsetsCytokinesTransforming Growth Factor betaReceptors, Interleukin-1Mice, KnockoutTh1 Cells
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References
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Nature Immunology · 2005 · 4,203 citations
Interleukin‐2 is essential for CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cell function
European Journal of Immunology · 2004 · 530 citations
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
Nature Immunology · 2005 · 2,654 citations
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
The Journal of Experimental Medicine · 2005 · 4,029 citations
Interleukin-17 Family Members and Inflammation
Immunity · 2004 · 2,349 citations
Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12
Immunity · 2000 · 2,788 citations
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
The Journal of Experimental Medicine · 1998 · 2,598 citations
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Nature Immunology · 2005 · 4,662 citations
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