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A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
Archives of General Psychiatry · 2006 · Vol. 63(8) · pp. 856–856
Carlos A. Zarate✉(National Institute of Mental Health)Jaskaran SinghPaul J. CarlsonNancy E. BrutschéRezvan AmeliDavid A. LuckenbaughDennis S. CharneyHusseini K. Manji
Abstract
Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week.
Treatment of Major DepressionTryptophan and brain disordersNeurotransmitter Receptor Influence on BehaviorPlaceboRandomized controlled trialDepression (economics)MoodKetamine hydrochlorideMedicineAntidepressantConfidence intervalCrossover studyInternal medicine
MeSH terms
AdultAntidepressive AgentsDepressive Disorder, MajorMajor Depressive DisorderDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleDrug ResistanceFemaleHumansInfusions, IntravenousKetamineMaleMiddle AgedPlacebos
Citations
3,706
FWCI
54.85
field-weighted impact
References
65
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100%
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