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Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis

Neuropsychopharmacology · 1999 · Vol. 20(2) · pp. 106–118
John W. Newcomer
Tryptophan and brain disordersTreatment of Major DepressionMemory and Neural MechanismsNMDA receptorBrief Psychiatric Rating ScaleKetaminePsychosisSchizophrenia (object-oriented programming)PsychologyGlutamate receptorPlaceboAntagonistVerbal memory

MeSH terms

AdultAnimalsCognitionDepression, ChemicalDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansInjections, IntravenousKetamineMaleMemory DisordersPsychoses, Substance-InducedMental RecallReceptors, N-Methyl-D-Aspartate

Funding

  • Deutsches Krebsforschungszentrum
  • National Alliance for Research on Schizophrenia and Depression
  • National Institute of Mental Health
Citations
598
FWCI
9.76
field-weighted impact
References
110
Percentile
99%
vs. same field & year
Citations per year
References
What are the functional consequences of neurocognitive deficits in schizophrenia?
American Journal of Psychiatry · 1996 · 3,501 citations
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Journal of Neurophysiology · 1989 · 2,712 citations
Diagnostic Interview for Genetic Studies
Archives of General Psychiatry · 1994 · 2,059 citations
Ketamine—Its Pharmacology and Therapeutic Uses
Anesthesiology · 1982 · 1,495 citations
Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans
Archives of General Psychiatry · 1994 · 3,315 citations
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Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis · Scinovex