articleTop 10% cited

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Nature Structural & Molecular Biology · 2004 · Vol. 11(12) · pp. 1192–1197

Jeffrey F. Ohren✉(Pfizer (United States))Huifen Chen(Pfizer (United States))A.G. Pavlovsky(Pfizer (United States))Christopher E. Whitehead(Pfizer (United States))Erli Zhang(Pfizer (United States))Peter Kuffa(AstraZeneca (United States))Chunhong Yan(Pfizer (United States))Patrick McConnell(Pfizer (United States))Cindy Spessard(Pfizer (United States))Craig Banotai(Pfizer (United States))W. Thomas Mueller(Pfizer (United States))Amy M. Delaney(Pfizer (United States))Charles A. Omer(University of Michigan–Ann Arbor)Judith S. Sebolt–Leopold(Pfizer (United States))David T. Dudley(Pfizer (United States))Iris Leung(Pfizer (United States))Cathlin Flamme(Pfizer (United States))Joseph S. Warmus(Pfizer (United States))Michael D. Kaufman(Pfizer (United States))Stephen D. Barrett(Pfizer (United States))Haile Tecle(Pfizer (United States))Charles A. Hasemann(Pfizer (United States))

View via DOI Publisher page

Melanoma and MAPK Pathways Protein Kinase Regulation and GTPase Signaling Protein Tyrosine PhosphatasesProtein kinase AMitogen-activated protein kinase kinaseKinaseCyclin-dependent kinase 2c-RafCell biologyChemistryMAP kinase kinase kinaseMAP2K7ASK1

MeSH terms

Binding SitesEnzyme InhibitorsHumansModels, MolecularMolecular StructureConserved SequenceDimerizationProtein Structure, QuaternaryStructural Homology, ProteinMAP Kinase Kinase 1MAP Kinase Kinase 2

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614

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9.13

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