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Comprehensive analysis of kinase inhibitor selectivity

Nature Biotechnology · 2011 · Vol. 29(11) · pp. 1046–1051

Mindy I. Davis✉Jeremy P. Hunt(National Institutes of Health)Sanna HerrgårdPietro Ciceri(National Institutes of Health)Lisa Wodicka(National Institutes of Health)Gabriel Pallares(National Institutes of Health)Michael HöckerDaniel K. Treiber(National Institutes of Health)Patrick P. Zarrinkar(National Institutes of Health)

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14-3-3 protein interactions Computational Drug Discovery Methods Protein Kinase Regulation and GTPase SignalingKinomeKinaseSubfamilyComputational biologyDrug discoveryBiologyBiochemistryChemistryGene

MeSH terms

CatalysisEnzyme StabilityHumansProtein BindingProtein KinasesSubstrate SpecificityDrug DesignSignal TransductionProteomicsProtein Kinase InhibitorsHigh-Throughput Screening Assays

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References

The specificities of protein kinase inhibitors: an update

Biochemical Journal · 2003 · 1,355 citations

The Protein Kinase Complement of the Human Genome

Science · 2002 · 8,071 citations

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Nature Structural & Molecular Biology · 2004 · 614 citations

A quantitative analysis of kinase inhibitor selectivity

Nature Biotechnology · 2008 · 2,427 citations

A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)

Cancer Research · 2004 · 1,108 citations

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