article Open AccessTop 10% cited
Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice
Arteriosclerosis Thrombosis and Vascular Biology · 2003 · Vol. 23(4) · pp. 656–660
Hirokazu Kirii✉(The University of Tokyo)Tamikazu Niwa(The University of Tokyo)Yasuhiro Yamada(The University of Tokyo)Hisayasu Wada(The University of Tokyo)Kuniaki Saito(The University of Tokyo)Yoichiro Iwakura(The University of Tokyo)Masahide Asano(The University of Tokyo)Hisataka Moriwaki(The University of Tokyo)Mitsuru Seishima(The University of Tokyo)
Abstract
The lack of IL-1beta decreases the severity of atherosclerosis in apoE deficient mice, possibly through increased expressions of VCAM-1 and monocyte chemotactic protein-1 in the aorta.
Atherosclerosis and Cardiovascular DiseasesAdipokines, Inflammation, and Metabolic DiseasesCell Adhesion Molecules ResearchApolipoprotein EProinflammatory cytokineMonocyteInterleukinAortaInflammationMedicineInternal medicineChemotaxisAortic sinus
MeSH terms
AnimalsAortaAortic Valve StenosisApolipoproteins EArteriosclerosisCell MovementGene Expression RegulationInterleukin-1LipidsMacrophagesMaleMice, Inbred C57BLMonocytesRNA, MessengerTunica Intima
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