review Open AccessTop 1% cited
Role of oxidized low density lipoprotein in atherogenesis.
Journal of Clinical Investigation · 1991 · Vol. 88(6) · pp. 1785–1792
Joseph L. Witztum✉(University of California, San Diego)Daniel Steinberg(University of California, San Diego)
Abstract
Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.
Antioxidant Activity and Oxidative StressAtherosclerosis and Cardiovascular DiseasesVitamin C and Antioxidants ResearchThrombosisOxidative phosphorylationLipoproteinLow-density lipoproteinVasomotorCholesterolLesionInternal medicineMedicineEndocrinology
MeSH terms
AnimalsArteriosclerosisHumansLipoproteins, LDLOxidation-Reduction
Citations
2,670
FWCI
35.05
field-weighted impact
References
62
Percentile
100%
vs. same field & year
Citations per year
Cited by
The Response-to-Retention Hypothesis of Early Atherogenesis
Arteriosclerosis Thrombosis and Vascular Biology · 1995 · 1,399 citations
Paraoxonase and Atherosclerosis
Arteriosclerosis Thrombosis and Vascular Biology · 2001 · 814 citations
Lipid Oxidation Products Have Opposite Effects on Calcifying Vascular Cell and Bone Cell Differentiation
Arteriosclerosis Thrombosis and Vascular Biology · 1997 · 616 citations
Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice
Arteriosclerosis Thrombosis and Vascular Biology · 2003 · 735 citations
The Yin and Yang of Oxidation in the Development of the Fatty Streak
Arteriosclerosis Thrombosis and Vascular Biology · 1996 · 693 citations
Antiinflammatory Properties of HDL
Circulation Research · 2004 · 1,351 citations
Upregulation of VCAM-1 and ICAM-1 at Atherosclerosis-Prone Sites on the Endothelium in the ApoE-Deficient Mouse
Arteriosclerosis Thrombosis and Vascular Biology · 1998 · 907 citations
Obesity and Systemic Oxidative Stress
Arteriosclerosis Thrombosis and Vascular Biology · 2003 · 1,296 citations
References
Beyond Cholesterol
New England Journal of Medicine · 1989 · 6,424 citations
LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture
Atherosclerosis · 1979 · 508 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.