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Preclinical Pharmacokinetics of Ranibizumab (rhuFabV2) after a Single Intravitreal Administration
Investigative Ophthalmology & Visual Science · 2005 · Vol. 46(2) · pp. 726–726
Abstract
This study demonstrates that ranibizumab has a PK profile that is favorable for its clinical use in treating neovascular AMD by monthly ITV injection.
Retinal Diseases and TreatmentsAngiogenesis and VEGF in CancerComplement system in diseasesRanibizumabPharmacokineticsMedicineIntravitreal administrationBioavailabilityMacular degenerationClearanceOphthalmologyPharmacologyChoroidal neovascularization
MeSH terms
RanibizumabAnimalsAntibodies, MonoclonalAqueous HumorBiological AvailabilityDrug Evaluation, PreclinicalFemaleHalf-LifeImmunoglobulin Fab FragmentsInjectionsMacaca fascicularisMaleRecombinant Fusion ProteinsRetinaVitreous Body
Citations
502
FWCI
28.17
field-weighted impact
References
35
Percentile
100%
vs. same field & year
Citations per year
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Prevention of Experimental Choroidal Neovascularization With Intravitreal Anti–Vascular Endothelial Growth Factor Antibody Fragment
Archives of Ophthalmology · 2002 · 588 citations
Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy
American Journal of Ophthalmology · 1994 · 1,290 citations
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Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor
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