articleTop 10% cited

Predicted biological activity of intravitreal VEGF Trap

British Journal of Ophthalmology · 2008 · Vol. 92(5) · pp. 667–668

Michael W. Stewart✉(Jacksonville College)Philip J. Rosenfeld(Ophthalmology Associates (United States))

Abstract

On the basis of this mathematical model, VEGF Trap maintains significant intravitreal VEGF-binding activity for 10-12 weeks after a single injection.

Retinal Diseases and Treatments Retinal Imaging and Analysis Retinopathy of Prematurity StudiesMedicineVEGF receptorsOphthalmologyTrap (plumbing)Internal medicine

MeSH terms

RanibizumabAnimalsAntibodies, MonoclonalDose-Response Relationship, DrugHalf-LifeImmunoglobulin Fab FragmentsInjectionsMacular DegenerationRabbitsRecombinant Fusion ProteinsVitreous BodyAngiogenesis InhibitorsModels, AnimalVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2

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371

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9.02

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98%

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Cited by

Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA)