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Increased expression of angiogenic growth factors in age-related maculopathy

British Journal of Ophthalmology · 1997 · Vol. 81(2) · pp. 154–162

Mike Kliffen✉(Erasmus University Rotterdam)Hari S. Sharma(Erasmus University Rotterdam)Cornelia M. Mooy(Erasmus University Rotterdam)SONJA KERKVLIET(Combined Ophthalmic Research Rotterdam)P.T.V.M. de Jong(Erasmus University Rotterdam)

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Abstract

These results demonstrate an increased expression of VEGF in the RPE, and in the outer nuclear layer in maculae with ARM, that could be involved in the pathogenesis of neovascular macular degeneration. Furthermore, enhanced TGF-beta expression in the RPE cells of maculae with early stages of ARM was shown.

Retinal Diseases and Treatments Retinal Imaging and Analysis Glaucoma and retinal disordersMacular degenerationMaculopathyRetinal pigment epitheliumVascular endothelial growth factorRetinalMedicineRetinaAge-related maculopathyGrowth factorOphthalmology

MeSH terms

AdultAgedAged, 80 and overGrowth SubstancesHumansImmunoenzyme TechniquesLymphokinesMacula LuteaMacular DegenerationMiddle AgedNeovascularization, PathologicPigment Epithelium of EyePlatelet-Derived Growth FactorTransforming Growth Factor betaFibroblast Growth Factor 2

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