Scinovex
reviewTop 1% cited

Targeting RAS signalling pathways in cancer therapy

Nature reviews. Cancer · 2003 · Vol. 3(1) · pp. 11–22
Julian Downward
PI3K/AKT/mTOR signaling in cancerMelanoma and MAPK PathwaysProtein Kinase Regulation and GTPase SignalingSignalling pathwaysSignallingSignal transductionCancer researchBiologyHedgehog signaling pathwayUpstream and downstream (DNA)Anti-apoptotic Ras signalling cascadeCancer therapyCancer

MeSH terms

AnimalsAntineoplastic AgentsHumansNeoplasmsGenes, rasDrug DesignSignal Transductionras ProteinsGTP Phosphohydrolase Activators
Citations
3,219
FWCI
36.79
field-weighted impact
References
88
Percentile
100%
vs. same field & year
Citations per year
References
Increasing complexity of Ras signaling
Oncogene · 1998 · 1,075 citations
Molecular alterations of the <i>AKT</i>2 oncogene in ovarian and breast carcinomas
International Journal of Cancer · 1995 · 836 citations
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
Journal of Biological Chemistry · 1998 · 3,023 citations
PTEN: Life as a Tumor Suppressor
Experimental Cell Research · 2001 · 679 citations
Small GTP-Binding Proteins
Physiological Reviews · 2001 · 2,461 citations
Cellular survival: a play in three Akts
Genes & Development · 1999 · 4,218 citations
Mutations of the BRAF gene in human cancer
Nature · 2002 · 10,619 citations
Related articles
Targeting RAS signalling pathways in cancer therapy
Nature reviews. Cancer · 2003 · 3,219 citations
Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.