review Open AccessTop 1% cited
The Two TORCs and Akt
Developmental Cell · 2007 · Vol. 12(4) · pp. 487–502
Prashanth T. Bhaskar✉(University of Illinois Chicago)Nissim Hay(University of Illinois Chicago)
PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingGenomics, phytochemicals, and oxidative stressBiologyProtein kinase BProto-Oncogene Proteins c-aktEmbryonic stem cellPI3K/AKT/mTOR pathwayCancerNeuroscienceCell biologySignal transductionGenetics
MeSH terms
AnimalsGene Expression RegulationHumansModels, BiologicalNeoplasmsPhosphoproteinsTranscription FactorsSignal TransductionTrans-ActivatorsConserved SequenceProtein Serine-Threonine KinasesMice, KnockoutEvolution, MolecularFetal DevelopmentProto-Oncogene Proteins c-akt
Funding
- National Institutes of Health
Citations
795
FWCI
29.62
field-weighted impact
References
162
Percentile
100%
vs. same field & year
Citations per year
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Molecular Cell · 2006 · 2,633 citations
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
Oncogene · 2004 · 1,243 citations
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
Developmental Cell · 2006 · 1,398 citations
FOXO transcription factors at the interface between longevity and tumor suppression
Oncogene · 2005 · 1,297 citations
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology · 2002 · 3,038 citations
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
Genes & Development · 2003 · 1,900 citations
Molecular alterations of the <i>AKT</i>2 oncogene in ovarian and breast carcinomas
International Journal of Cancer · 1995 · 836 citations
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