article Open AccessTop 1% cited

Mutations of the BRAF gene in human cancer

Nature · 2002 · Vol. 417(6892) · pp. 949–954

Helen Davies✉(Wellcome Sanger Institute)Graham R. Bignell(Wellcome Sanger Institute)Charles Cox(Wellcome Sanger Institute)Philip Stephens(Wellcome Sanger Institute)Sarah Edkins(Wellcome Sanger Institute)Sheila Clegg(Wellcome Sanger Institute)Jon W. Teague(Wellcome Sanger Institute)Hayley Woffendin(Wellcome Sanger Institute)Mathew J. Garnett(Cancer Research UK)William Bottomley(Wellcome Sanger Institute)Neil M. Davis(Wellcome Sanger Institute)Ed Dicks(Wellcome Sanger Institute)Rebecca Ewing(Wellcome Sanger Institute)Yvonne Floyd(Wellcome Sanger Institute)Kristian Gray(Wellcome Sanger Institute)Sarah Hall(Wellcome Sanger Institute)Rachel Hawes(Wellcome Sanger Institute)Jaime Hughes(Wellcome Sanger Institute)Vivian Kosmidou(Wellcome Sanger Institute)Andrew Menzies(Wellcome Sanger Institute)Catherine Mould(Wellcome Sanger Institute)Adrian G. Parker(Wellcome Sanger Institute)Claire Stevens(Wellcome Sanger Institute)Stephen Watt(Wellcome Sanger Institute)Steven Hooper(Cancer Research UK)Rebecca Wilson(Cancer Research UK)Hiran Jayatilake(Institute of Cancer Research)Barry A. Gusterson(University of Glasgow)Colin Cooper(Institute of Cancer Research)Janet Shipley(Institute of Cancer Research)Darren Hargrave(Institute of Cancer Research)Kathy Pritchard‐Jones(Institute of Cancer Research)Norman J. Maitland(Yorkshire Cancer Research)Georgia Chenevix‐Trench(QIMR Berghofer Medical Research Institute)Gregory J. Riggins(Duke University)Darell D. Bigner(Duke University)Giuseppe Palmieri(Institute of Genetics and Biophysics)Antonio Cossu(University of Sassari)Adrienne M. Flanagan(University College London)Andrew G. Nicholson(Royal Brompton Hospital)Judy Ho(University of Hong Kong)Suet Yi Leung(Queen Mary Hospital)Siu Tsan Yuen(Queen Mary Hospital)Barbara L. Weber(UPMC Hillman Cancer Center)Hilliard F. Seigler(Duke University)Timothy L. Darrow(Duke University)Hugh Paterson(Cancer Research UK)Richard Marais(Institute of Cancer Research)Christopher J. Marshall(Cancer Research UK)Richard Wooster(Institute of Cancer Research)Michael R. Stratton(Institute of Cancer Research)P. Andrew Futreal(Wellcome Sanger Institute)

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Melanoma and MAPK Pathways PI3K/AKT/mTOR signaling in cancer Cancer Mechanisms and TherapyBiologyCancer researchSomatic cellKinaseMutationPoint mutationGeneMissense mutationCancerProtein kinase domain

MeSH terms

Amino Acid SequenceAnimalsBase SequenceCell DivisionCell Transformation, NeoplasticDNA Mutational AnalysisEnzyme ActivationHumansMelanomaMolecular Sequence DataNeoplasmsTumor Cells, Cultured3T3 CellsProtein Structure, Tertiaryras Proteins

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