reviewTop 1% cited
PTEN: Life as a Tumor Suppressor
Experimental Cell Research · 2001 · Vol. 264(1) · pp. 29–41
Laura J. SimpsonRamon Parsons✉(Columbia University)
PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex ResearchKruppel-like factors researchPTENBiologyPI3K/AKT/mTOR pathwayProtein kinase BPhosphatidylinositolPhosphataseSuppressorKinaseCell biologyCancer research
MeSH terms
AnimalsCell CycleChromosomes, Human, Pair 10ForecastingHamartoma Syndrome, MultipleHumansNeoplasmsPhosphoric Monoester HydrolasesSignal TransductionGenes, Tumor SuppressorProtein Tyrosine PhosphatasesApoptosisProtein Structure, TertiaryLoss of HeterozygosityPhosphatidylinositol 3-Kinases
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References
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
Nature Genetics · 1997 · 2,757 citations
The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate
Journal of Biological Chemistry · 1998 · 3,080 citations
Mutation and Cancer: Statistical Study of Retinoblastoma
Proceedings of the National Academy of Sciences · 1971 · 7,578 citations
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
Human Molecular Genetics · 1998 · 658 citations
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Cell · 1999 · 6,532 citations
Cellular survival: a play in three Akts
Genes & Development · 1999 · 4,218 citations
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
Nature Genetics · 1997 · 2,083 citations
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