article Open AccessTop 1% cited
Mechanism of activation of protein kinase B by insulin and IGF-1.
The EMBO Journal · 1996 · Vol. 15(23) · pp. 6541–6551
Dario R. Alessi✉(University of Dundee)Mirjana Andjelković(MRC Protein Phosphorylation and Ubiquitylation Unit)B. Caudwell(University of Dundee)Peter Cron(University of Dundee)Nick Morrice(University of Dundee)Philip Cohen(MRC Protein Phosphorylation and Ubiquitylation Unit)Brian A. Hemmings(University of Dundee)
Protein Kinase Regulation and GTPase SignalingMetabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancerPhosphorylationProtein phosphorylationBiologyUnit (ring theory)Protein kinase ABiochemistryPsychology
MeSH terms
Amino Acid SequenceAnimalsCell LineEnzyme ActivationHumansInsulinInsulin-Like Growth Factor IKineticsL CellsMolecular Sequence DataPhosphorylationProto-Oncogene ProteinsRecombinant ProteinsSerineThreonine
Funding
- Royal Society
- Medical Research Council
Citations
3,023
FWCI
33.24
field-weighted impact
References
32
Percentile
100%
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References
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1
FEBS Letters · 1995 · 2,089 citations
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
Gene · 1989 · 7,496 citations
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
Analytical Biochemistry · 1976 · 225,297 citations
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