articleTop 1% cited
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Nature Cell Biology · 2007 · Vol. 9(3) · pp. 316–323
Emilie Vander Haar✉(University of Minnesota)Seong-il Lee(University of Minnesota)Sricharan Bandhakavi(University of Minnesota)Timothy J. Griffin(University of Minnesota)Do‐Hyung Kim(University of Minnesota)
PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingPolyamine Metabolism and ApplicationsPI3K/AKT/mTOR pathwayProtein kinase BmTORC2RPTORPhosphorylationCell biologyBiologymTORC1ChemistryCancer research
MeSH terms
Regulatory-Associated Protein of mTORAnimalsAntimycin ACell LineDeoxyglucoseHumansInsulinModels, BiologicalPhosphoproteinsPhosphorylationProtein BindingProtein KinasesProteinsTransfectionSignal Transduction
Funding
- Tuberous Sclerosis Alliance
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1,164
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References
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology · 2002 · 3,038 citations
Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton
Current Biology · 2004 · 2,646 citations
Rheb Binds and Regulates the mTOR Kinase
Current Biology · 2005 · 986 citations
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
Molecular Cell · 2002 · 1,548 citations
Empirical Statistical Model To Estimate the Accuracy of Peptide Identifications Made by MS/MS and Database Search
Analytical Chemistry · 2002 · 4,963 citations
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Nature Cell Biology · 2004 · 2,097 citations
Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control
Molecular Cell · 2002 · 1,883 citations
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