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Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
Molecular Cell · 2001 · Vol. 7(6) · pp. 1165–1176
Donalyn Scheuner(Howard Hughes Medical Institute)Benbo Song(University of Michigan)Edward L. McEwen(Howard Hughes Medical Institute)Chuan Liu(University of Michigan)D. Ross Laybutt(Joslin Diabetes Center)Patrick J. Gillespie(University of Michigan)Thomas L. Saunders(University of Michigan)Susan Bonner‐Weir(Joslin Diabetes Center)Randal J. Kaufman✉(Howard Hughes Medical Institute)
Endoplasmic Reticulum Stress and DiseaseRNA regulation and diseasePancreatic function and diabetesBiologyUnfolded protein responseEndoplasmic reticulumPhosphorylationEukaryotic initiation factorTranslational regulationeIF2Translation (biology)Glucose homeostasisCell biology
MeSH terms
Endoplasmic Reticulum Chaperone BiPAnimalsAnimals, NewbornBlood ProteinsCarrier ProteinsCell SurvivalDNA-Binding ProteinsEndoplasmic ReticulumGluconeogenesisGlucoseHeat-Shock ProteinsHomeostasisHomozygoteHypoglycemiaIslets of Langerhans
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1,342
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References
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
Nature Cell Biology · 2000 · 2,842 citations
Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response
Molecular Cell · 2000 · 1,997 citations
Initiation of Protein Synthesis in Eukaryotic Cells
European Journal of Biochemistry · 1996 · 712 citations
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
Genes & Development · 1999 · 2,249 citations
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Molecular Cell · 2000 · 3,216 citations
Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress
Molecular Biology of the Cell · 1999 · 2,020 citations
Translational control
Journal of Cellular Biochemistry · 1991 · 432 citations
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