articleTop 1% cited
Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour
Critical Care Medicine · 2014 · Vol. 42(8) · pp. 1749–1755
Ricard Ferrer✉Ignacio Martín‐LoechesGary Phillips(The Ohio State University)Tiffany M. OsbornSean R. Townsend(California Pacific Medical Center)R. Phillip Dellinger(Brown University)Antonio ArtigasChrista Schorr(Brown University)Mitchell M. Levy(Cooper University Hospital)
Abstract
The results of the analysis of this large population of patients with severe sepsis and septic shock demonstrate that delay in first antibiotic administration was associated with increased in-hospital mortality. In addition, there was a linear increase in the risk of mortality for each hour delay in antibiotic administration. These results underscore the importance of early identification and treatment of septic patients in the hospital setting.
Sepsis Diagnosis and TreatmentNosocomial Infections in ICUBacterial Identification and Susceptibility TestingMedicineSeptic shockSepsisSurviving Sepsis CampaignAntibioticsRetrospective cohort studyResuscitationEmergency departmentPopulationEmergency medicine
MeSH terms
Anti-Bacterial AgentsEuropeFemaleHumansIntensive Care UnitsMalePatient AdmissionRetrospective StudiesShock, SepticSouth AmericaTime FactorsUnited StatesCohort StudiesHospital MortalityGuidelines as Topic
Citations
1,445
FWCI
69.93
field-weighted impact
References
19
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100%
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Citations per year
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New England Journal of Medicine · 2001 · 10,728 citations
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