articleTop 1% cited
Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department*
Critical Care Medicine · 2010 · Vol. 38(4) · pp. 1045–1053
David F. Gaieski✉(University of Pennsylvania)Mark E. Mikkelsen(University of Pennsylvania)Roger A. Band(University of Pennsylvania)Jesse M. Pines(University of Pennsylvania)Richard Massone(University of Pennsylvania)Frances F. Furia(University of Pennsylvania)Frances S. Shofer(University of Pennsylvania)Munish Goyal(University of Pennsylvania)
Abstract
Elapsed times from triage and qualification for early goal-directed therapy to administration of appropriate antimicrobials are primary determinants of mortality in patients with severe sepsis and septic shock treated with early goal-directed therapy.
Sepsis Diagnosis and TreatmentClinical Reasoning and Diagnostic SkillsHemodynamic Monitoring and TherapyMedicineInterquartile rangeTriageSeptic shockOdds ratioConfidence intervalSepsisEmergency departmentEarly goal-directed therapyAntibiotics
MeSH terms
AdultAgedAged, 80 and overAnti-Bacterial AgentsClinical ProtocolsEmergenciesEmergency Service, HospitalFemaleHumansMaleMiddle AgedRetrospective StudiesShock, SepticTime FactorsCohort Studies
Citations
958
FWCI
31.31
field-weighted impact
References
18
Percentile
100%
vs. same field & year
Citations per year
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References
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*
Critical Care Medicine · 2006 · 6,021 citations
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
Critical Care Medicine · 2001 · 8,573 citations
Chart Reviews In Emergency Medicine Research: Where Are The Methods?
Annals of Emergency Medicine · 1996 · 1,151 citations
Delaying the Empiric Treatment of <i>Candida</i> Bloodstream Infection until Positive Blood Culture Results Are Obtained: a Potential Risk Factor for Hospital Mortality
Antimicrobial Agents and Chemotherapy · 2005 · 1,268 citations
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