article Open AccessTop 1% cited
Assessment of Clinical Criteria for Sepsis
JAMA · 2016 · Vol. 315(8) · pp. 762–762
Christopher W. Seymour✉(University of Pittsburgh)Jean‐Louis Vincent(Kaiser Permanente)Theodore J. Iwashyna(VA Center for Clinical Management Research)Frank M. Brunkhorst(Jena University Hospital)Thomas D. Rea(University of Washington)André Scherag(Jena University Hospital)Gordon D. Rubenfeld(Health Sciences Centre)Jeremy M. Kahn(University of Pittsburgh)Manu Shankar‐Hari(Guy's and St Thomas' NHS Foundation Trust)Mervyn Singer(University College London)Clifford S. Deutschman(Schneider Children's Hospital)Gabriel J. Escobar(VA Center for Clinical Management Research)Derek C. Angus(University of Pittsburgh)
Abstract
Among ICU encounters with suspected infection, the predictive validity for in-hospital mortality of SOFA was not significantly different than the more complex LODS but was statistically greater than SIRS and qSOFA, supporting its use in clinical criteria for sepsis. Among encounters with suspected infection outside of the ICU, the predictive validity for in-hospital mortality of qSOFA was statistically greater than SOFA and SIRS, supporting its use as a prompt to consider possible sepsis.
Sepsis Diagnosis and TreatmentHemodynamic Monitoring and TherapyCardiac, Anesthesia and Surgical OutcomesMedicineSepsisIntensive care medicineMedical physicsInternal medicine
MeSH terms
AdultFemaleHumansHypotensionInfectionsIntensive Care UnitsLength of StayMalePennsylvaniaRegression AnalysisRetrospective StudiesReproducibility of ResultsHospital MortalitySystemic Inflammatory Response SyndromeSepsis
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3,698
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