articleTop 1% cited
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*
Critical Care Medicine · 2006 · Vol. 34(6) · pp. 1589–1596
Anand Kumar✉(University of Manitoba)Daniel RobertsKenneth E. WoodBruce LightJoseph E. ParrilloSatendra SharmaRobert SuppesDaniel FeinsteinSergio ZanottiLeo TaibergDavid P. GurkaAseem Kumar(University of Manitoba)Mary Cheang
Abstract
Effective antimicrobial administration within the first hour of documented hypotension was associated with increased survival to hospital discharge in adult patients with septic shock. Despite a progressive increase in mortality rate with increasing delays, only 50% of septic shock patients received effective antimicrobial therapy within 6 hrs of documented hypotension.
Sepsis Diagnosis and TreatmentHemodynamic Monitoring and TherapyRespiratory Support and MechanismsMedicineSeptic shockOdds ratioConfidence intervalRetrospective cohort studyShock (circulatory)AntimicrobialMortality rateMedical recordCohort study
MeSH terms
AdultAnti-Infective AgentsFemaleFollow-Up StudiesHumansHypotensionMaleManitobaMiddle AgedPatient DischargeRetrospective StudiesShock, SepticTime FactorsUnited StatesPrevalence
Citations
6,021
FWCI
89.37
field-weighted impact
References
34
Percentile
100%
vs. same field & year
Citations per year
Cited by
Therapeutic drug monitoring of antimicrobials
British Journal of Clinical Pharmacology · 2011 · 308 citations
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)
Critical Care Medicine · 2020 · 1,612 citations
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Critical Care Medicine · 2017 · 3,780 citations
Sepsis: a roadmap for future research
The Lancet Infectious Diseases · 2015 · 999 citations
Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department*
Critical Care Medicine · 2010 · 958 citations
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
Intensive Care Medicine · 2007 · 4,939 citations
Surviving Sepsis Campaign
Critical Care Medicine · 2013 · 9,702 citations
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
Intensive Care Medicine · 2013 · 7,321 citations
References
APACHE II-A Severity of Disease Classification System
Critical Care Medicine · 1986 · 13,403 citations
Clinical Importance of Delays in the Initiation of Appropriate Antibiotic Treatment for Ventilator-Associated Pneumonia
CHEST Journal · 2002 · 965 citations
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
New England Journal of Medicine · 2001 · 10,728 citations
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Intensive Care Medicine · 2004 · 3,341 citations
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
CHEST Journal · 1992 · 13,160 citations
Surviving Sepsis Campaign Management Guidelines Committee. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Critical Care Medicine · 2004 · 1,852 citations
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Critical Care Medicine · 2004 · 3,039 citations
APACHE II
Critical Care Medicine · 1985 · 13,529 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.