articleTop 10% cited
The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity
Journal of Pharmacology and Experimental Therapeutics · 2003 · Vol. 306(1) · pp. 287–300
Bryan A. Ward✉(Indiana University School of Medicine)J. Christopher Gorski(Indiana University Bloomington)David R. JonesStephen D. Hall(Indiana University Bloomington)David A. FlockhartZeruesenay Desta
HIV/AIDS drug development and treatmentHIV Research and TreatmentHIV-related health complications and treatmentsEfavirenzCYP2B6ChemistryHydroxylationSubstrate (aquarium)MicrosomeCytochrome P450KineticsMetabolismCYP1A2
MeSH terms
AlkynesAryl Hydrocarbon HydroxylasesBiotransformationCatalysisCyclopropanesHIVHumansMicrosomes, LiverOxazinesOxidoreductases, N-DemethylatingRecombinant ProteinsHIV InfectionsAnti-HIV AgentsBenzoxazinesCytochrome P-450 CYP2B6
Citations
591
FWCI
10.00
field-weighted impact
References
39
Percentile
99%
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Citations per year
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References
Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
AIDS · 2001 · 832 citations
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
Analytical Biochemistry · 1976 · 225,297 citations
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
Journal of Pharmacology and Experimental Therapeutics · 1994 · 2,779 citations
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