articleTop 1% cited

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Journal of Pharmacology and Experimental Therapeutics · 1994 · Vol. 270(1) · pp. 414–423

Tsutomu Shimada✉(Osaka Prefectural Institute of Public Health)Hiroshi Yamazaki(Osaka Prefectural Institute of Public Health)Mayumi Mimura(Osaka Prefectural Institute of Public Health)Yukiharu Inui(Osaka Prefectural Institute of Public Health)F. Peter Guengerich(Osaka Prefectural Institute of Public Health)

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Pharmacogenetics and Drug Metabolism Carcinogens and Genotoxicity Assessment Chemical Reactions and IsotopesCytochromeMicrosomeCarcinogenEnzymeInternal medicineCytochrome P450ChemistryEndocrinologyBiochemistryBiology

MeSH terms

AdolescentAdultAgedAgingBiotransformationCarcinogensChildCytochrome P-450 Enzyme SystemPharmaceutical PreparationsFemaleHumansIndividualityInfantIsoenzymesJapan

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Generation of a Set of Simple, Interpretable ADMET Rules of Thumb