articleTop 1% cited
Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6
Journal of Pharmacology and Experimental Therapeutics · 2004 · Vol. 310(3) · pp. 1062–1075
Zeruesenay Desta✉(Indiana University School of Medicine)Bryan A. Ward(Indiana University – Purdue University Indianapolis)Nadia Soukhova(Georgetown University)David A. Flockhart
Pharmacogenetics and Drug MetabolismEstrogen and related hormone effectsInflammatory mediators and NSAID effectsCYP3ABiotransformationDesmethylMetaboliteChemistryCytochrome P450CYP3A4Primary metaboliteCYP2D6CYP2B6
MeSH terms
BiotransformationCytochrome P-450 Enzyme SystemHumansKineticsMicrosomes, LiverOxidation-ReductionStatistics as TopicTamoxifenCytochrome P-450 CYP2D6Cytochrome P-450 CYP3A
Citations
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FWCI
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field-weighted impact
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References
The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity
Journal of Pharmacology and Experimental Therapeutics · 2003 · 591 citations
A MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTIOESTROGENIC ACTIVITY
Journal of Endocrinology · 1977 · 502 citations
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
Analytical Biochemistry · 1976 · 225,297 citations
Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
JNCI Journal of the National Cancer Institute · 1998 · 5,500 citations
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Breast Cancer Research and Treatment · 2004 · 455 citations
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
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