reviewTop 1% cited
Signaling by Distinct Classes of Phosphoinositide 3-Kinases
Experimental Cell Research · 1999 · Vol. 253(1) · pp. 239–254
Bart Vanhaesebroeck✉(Ludwig Cancer Research)Michael D. Waterfield(Ludwig Cancer Research)
PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingUbiquitin and proteasome pathwaysPleckstrin homology domainBiologyCell biologySignal transductionGene isoformInositolPhosphoinositide 3-kinaseKinaseIntracellularExtracellular
MeSH terms
Phosphoinositide-3 Kinase InhibitorsAnimalsBinding SitesIsoenzymesSignal TransductionProtein Serine-Threonine KinasesProtein Structure, TertiaryMice, KnockoutPhosphatidylinositol 3-KinasesMice
Citations
854
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173
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100%
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References
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
Journal of Biological Chemistry · 1994 · 3,250 citations
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
Biochemical Journal · 1998 · 957 citations
Phosphoinositide 3-kinases: A conserved family of signal transducers
Trends in Biochemical Sciences · 1997 · 945 citations
The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB
Experimental Cell Research · 1999 · 873 citations
Mechanisms and consequences of activation of protein kinase B/Akt
Current Opinion in Cell Biology · 1998 · 1,306 citations
Induction of NF-κB by the Akt/PKB kinase
Current Biology · 1999 · 852 citations
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
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