reviewTop 1% cited
Signalling through phosphoinositide 3-kinases: the lipids take centre stage
Current Opinion in Cell Biology · 1999 · Vol. 11(2) · pp. 219–225
Sally J. Leevers✉(Department of Science and Technology)Bart Vanhaesebroeck✉(Ludwig Cancer Research)Michael D. Waterfield✉(University College London)
PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingMetabolism, Diabetes, and CancerPleckstrin homology domainBiologyInositolPiPTENCell biologyKinasePhosphorylationPhosphatidylinositolSignal transduction
MeSH terms
Amino Acid SequenceAnimalsBlood ProteinsEnzyme ActivationHumansIsoenzymesMembrane LipidsModels, BiologicalNeoplasm ProteinsPhosphatidylinositolsPhosphoric Monoester HydrolasesPhosphoproteinsPhosphorylationProtein Processing, Post-TranslationalProtein-Tyrosine Kinases
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681
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26.18
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55
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References
Phosphoinositide 3-kinases: A conserved family of signal transducers
Trends in Biochemical Sciences · 1997 · 945 citations
Mechanisms and consequences of activation of protein kinase B/Akt
Current Opinion in Cell Biology · 1998 · 1,306 citations
The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate
Journal of Biological Chemistry · 1998 · 3,080 citations
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Current Biology · 1997 · 2,824 citations
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