reviewTop 1% cited
Nrf2 signaling in coordinated activation of antioxidant gene expression
Free Radical Biology and Medicine · 2004 · Vol. 36(10) · pp. 1199–1207
Anil K. Jaiswal✉(Baylor College of Medicine)
Genomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsPlant Stress Responses and ToleranceNRF1Cell biologyTranscription factorSignal transductionGene expressionCytosolRegulation of gene expressionPhosphorylationKEAP1Protein kinase C
MeSH terms
AnimalsAntioxidantsDNA-Binding ProteinsHumansPhosphorylationProtein Kinase CSignal TransductionTrans-ActivatorsGene Expression Regulation, EnzymologicNAD(P)H Dehydrogenase (Quinone)Response ElementsNF-E2-Related Factor 2
Funding
- National Institutes of Health
Citations
1,236
FWCI
12.61
field-weighted impact
References
95
Percentile
99%
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References
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Biochemical and Biophysical Research Communications · 1997 · 3,915 citations
Reactions of oxyl radicals with DNA
Free Radical Biology and Medicine · 1995 · 1,030 citations
Oxidants as Stimulators of Signal Transduction
Free Radical Biology and Medicine · 1997 · 1,374 citations
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Genes & Development · 1999 · 3,543 citations
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
Molecular and Cellular Biology · 2003 · 1,425 citations
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