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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Biochemical and Biophysical Research Communications · 1997 · Vol. 236(2) · pp. 313–322

Ken Itoh(University of Tsukuba)Tomoki Chiba(National Center of Neurology and Psychiatry)Satoru Takahashi(University of Tsukuba)Tetsuro Ishii(University of Tsukuba)Kazuhiko Igarashi(University of Tsukuba)Yasutake Katoh(University of Tsukuba)Tatsuya Oyake(Tohoku University)Norio Hayashi(Tohoku University)Kimihiko Satoh(Hirosaki University)Ichiro Hatayama(Hirosaki University)M. Yamamoto✉(University of Tsukuba)Yo-ichi Nabeshima(National Center of Neurology and Psychiatry)

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Genomics, phytochemicals, and oxidative stress Glutathione Transferases and Polymorphisms Plant Stress Responses and ToleranceTranscription factorEnzymeEnzyme inducerBiologyGeneIn vivoGene expressionMolecular biologyTranscription (linguistics)Biochemistry

MeSH terms

AnimalsBinding SitesButylated HydroxyanisoleDNA-Binding ProteinsGlutathione TransferaseHeterozygoteHomozygoteIntestinesLiverMalePromoter Regions, GeneticQuinone ReductasesTranscription FactorsXenobioticsTrans-Activators

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Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element