review Open AccessTop 1% cited
Interfering with pH regulation in tumours as a therapeutic strategy
Nature Reviews Drug Discovery · 2011 · Vol. 10(10) · pp. 767–777
Dario Neri✉Claudiu T. Supuran(University of Florence)
Enzyme function and inhibitionCancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismGene isoformIntracellular pHTransporterExtracellularCarbonic anhydraseSmall moleculeChemistryCancer cellIntracellularBiochemistry
MeSH terms
AcidosisAnimalsAntineoplastic AgentsBicarbonatesCarbonic Anhydrase InhibitorsHumansHydrogen-Ion ConcentrationNeoplasms
Funding
- National Science Foundation
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Eidgenössische Technische Hochschule Zürich
Citations
1,519
FWCI
42.98
field-weighted impact
References
118
Percentile
100%
vs. same field & year
Citations per year
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References
Tumor Cell Metabolism: Cancer's Achilles' Heel
Cancer Cell · 2008 · 2,271 citations
The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation
Biochemical Journal · 1999 · 1,308 citations
Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
Radiotherapy and Oncology · 2009 · 553 citations
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
Nature Reviews Drug Discovery · 2008 · 3,109 citations
An overview of inhibitors of Na+/H+ exchanger
European Journal of Medicinal Chemistry · 2003 · 438 citations
Hallmarks of Cancer: The Next Generation
Cell · 2011 · 65,668 citations
Carbonic anhydrase inhibitors
Bioorganic & Medicinal Chemistry Letters · 2010 · 610 citations
Why do cancers have high aerobic glycolysis?
Nature reviews. Cancer · 2004 · 4,733 citations
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