reviewTop 1% cited
Why do cancers have high aerobic glycolysis?
Nature reviews. Cancer · 2004 · Vol. 4(11) · pp. 891–899
Robert A. Gatenby✉(Applied Mathematics (United States))Robert J. Gillies(University of Arizona)
Cancer, Hypoxia, and MetabolismMitochondrial Function and PathologyMetabolomics and Mass Spectrometry StudiesDownregulation and upregulationGlycolysisAnaerobic glycolysisCarcinogenesisCancer researchCell growthWarburg effectBiologyPhenotypeCancer cell
MeSH terms
AcidosisCell Transformation, NeoplasticGlycolysisHumansNeoplasm InvasivenessNeoplasm MetastasisNeoplasmsNeovascularization, PathologicOxygenPhenotypeUp-RegulationCell Proliferation
Citations
4,733
FWCI
34.83
field-weighted impact
References
97
Percentile
100%
vs. same field & year
Citations per year
Cited by
Glycolysis inhibition for anticancer treatment
Oncogene · 2006 · 1,500 citations
Inhibitory effect of tumor cell–derived lactic acid on human T cells
Blood · 2007 · 1,838 citations
Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics
Oncotarget · 2012 · 408 citations
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Science · 2009 · 15,796 citations
Serum Metabolite Profiling of Human Colorectal Cancer Using GC−TOFMS and UPLC−QTOFMS
Journal of Proteome Research · 2009 · 398 citations
Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer
Nanomaterials · 2017 · 393 citations
Metabolic Modulation of Glioblastoma with Dichloroacetate
Science Translational Medicine · 2010 · 711 citations
The Warburg effect: 80 years on
Biochemical Society Transactions · 2016 · 501 citations
References
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
Cell · 1996 · 6,874 citations
Signal transduction to hypoxia-inducible factor 1
Biochemical Pharmacology · 2002 · 849 citations
A genetic model for colorectal tumorigenesis
Cell · 1990 · 12,052 citations
Targeting HIF-1 for cancer therapy
Nature reviews. Cancer · 2003 · 6,642 citations
The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
British Journal of Cancer · 1955 · 2,210 citations
The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue
The Journal of Physiology · 1919 · 1,425 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
