article Open AccessTop 1% cited
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
Molecular Psychiatry · 2008 · Vol. 14(5) · pp. 511–522
Jason C. O’Connor✉(University of Illinois System)Mark A. Lawson(Urbana University)Caroline André(NutriNeuro)Maïté Moreau(Centre National de la Recherche Scientifique)Jacques Lestage(NutriNeuro)Nathalie Castanon(Centre National de la Recherche Scientifique)Keith W. Kelley(University of Illinois Chicago)Robert Dantzer(University of Illinois Urbana-Champaign)
Tryptophan and brain disordersStress Responses and CortisolNeuroendocrine regulation and behaviorKynurenineIndoleamine 2,3-dioxygenaseKynurenine pathwayLipopolysaccharideInflammationSickness behaviorSerotoninProinflammatory cytokineCatabolismMediator
MeSH terms
AnimalsBehavior, AnimalChromatography, High Pressure LiquidCytokininsDepressionDisease Models, AnimalDose-Response Relationship, DrugEnzyme ActivationEnzyme InhibitorsGene Expression RegulationKynurenineLipopolysaccharidesMaleMice, Inbred ICRMinocycline
Funding
- National Institutes of Health
Citations
1,258
FWCI
11.75
field-weighted impact
References
56
Percentile
99%
vs. same field & year
Citations per year
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References
Neurobehavioral Effects of Interferon-α in Cancer Patients Phenomenology and Paroxetine Responsiveness of Symptom Dimensions
Neuropsychopharmacology · 2002 · 781 citations
Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism
Journal of Neurochemistry · 1991 · 759 citations
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Nature Medicine · 2003 · 2,279 citations
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Nature reviews. Immunology · 2004 · 2,302 citations
The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
Molecular Psychiatry · 2007 · 665 citations
Mood Disorders in the Medically Ill: Scientific Review and Recommendations
Biological Psychiatry · 2005 · 1,068 citations
The Proinflammatory Cytokines Interleukin-1beta and Tumor Necrosis Factor-Alpha Activate Serotonin Transporters
Neuropsychopharmacology · 2006 · 540 citations
From inflammation to sickness and depression: when the immune system subjugates the brain
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