reviewTop 1% cited
Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
Neuroscience & Biobehavioral Reviews · 2011 · Vol. 36(2) · pp. 764–785
Brian E. Leonard(Ollscoil na Gaillimhe – University of Galway)Michaël Maes✉
Tryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration MechanismsOxidative stressInflammationCytokineTumor necrosis factor alphaProinflammatory cytokineImmunologyEndocrinologyInternal medicineMedicine
MeSH terms
AnimalsAntidepressive AgentsDepressive DisorderHumansImmunity, CellularInflammationFatty Acids, Omega-3NitrosationCytokinesOxidative StressIndoleamine-Pyrrole 2,3,-Dioxygenase
Citations
812
FWCI
18.34
field-weighted impact
References
423
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100%
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Cited by
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CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression
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