article Open AccessTop 10% cited
The Proinflammatory Cytokines Interleukin-1beta and Tumor Necrosis Factor-Alpha Activate Serotonin Transporters
Neuropsychopharmacology · 2006 · Vol. 31(10) · pp. 2121–2131
Chong-Bin Zhu✉(Vanderbilt University)Randy Blakely(Vanderbilt University)William A. Hewlett(Vanderbilt University)
Tryptophan and brain disordersStress Responses and CortisolReceptor Mechanisms and SignalingSerotonin transporterProinflammatory cytokineEndocrinologyInternal medicineTumor necrosis factor alphaSerotonergicSerotoninp38 mitogen-activated protein kinasesMAPK/ERK pathwayBiology
MeSH terms
Analysis of VarianceAnimalsCell LineCorpus StriatumDose-Response Relationship, DrugDrug InteractionsEnzyme ActivationEnzyme InhibitorsInterleukin-1MesencephalonNeuronsRaphe NucleiSerotoninSynaptosomesTumor Necrosis Factor-alpha
Funding
- National Alliance for Research on Schizophrenia and Depression
- National Institute on Drug Abuse
Citations
540
FWCI
7.72
field-weighted impact
References
63
Percentile
98%
vs. same field & year
Citations per year
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References
Psychopharmacology: The Fourth Generation of Progress
Mayo Clinic Proceedings · 1995 · 782 citations
Cytokine‐Induced Sickness Behavior: Mechanisms and Implications
Annals of the New York Academy of Sciences · 2001 · 790 citations
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Science · 2003 · 8,097 citations
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