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Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents

Journal of Allergy and Clinical Immunology · 1997 · Vol. 100(4) · pp. 444–451

Hugh A. Sampson✉(University of Baltimore)Deborah G. Ho(University of Baltimore)

Abstract

When compared with the outcome of DBPCFCs, results of CAP System FEIA are generally comparable to those of skin prick tests in predicting symptomatic food hypersensitivity. Furthermore, by measuring the concentrations of food-specific IgE antibodies with the CAP System FEIA, it is possible to identify a subset of patients who are highly likely (>95%) to experience clinical reactions to egg, milk, peanut, or fish. This could eliminate the need to perform DBPCFCs in a significant number of patients suspected of having IgE-mediated food allergy.

Food Allergy and Anaphylaxis Research Allergic Rhinitis and Sensitization Asthma and respiratory diseasesMedicineImmunoglobulin EFood allergyGold standard (test)PopulationOral food challengeAllergyImmunologyEgg allergyAllergen

MeSH terms

AdolescentAdultAntibody SpecificityChildChild, PreschoolDouble-Blind MethodFemaleFood HypersensitivityHumansImmunoglobulin EInfantMalePlacebosPredictive Value of TestsReagent Kits, Diagnostic

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