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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Nature · 2001 · Vol. 411(6836) · pp. 494–498

Sayda M. Elbashir✉(Max Planck Institute for Biophysical Chemistry)Jens Harborth(Max Planck Society)Winfried Lendeckel(Max Planck Society)Abdullah Yalçın(Max Planck Society)Klaus Weber(Max Planck Society)Thomas Tuschl(Max Planck Society)

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RNA Interference and Gene Delivery RNA Research and Splicing Virus-based gene therapy researchRNA interferenceRNA silencingTrans-acting siRNARNARNA-induced transcriptional silencingSmall interfering RNABiologyRNA-induced silencing complexGene silencingDNA-directed RNA interference

MeSH terms

AnimalsColeopteraCells, CulturedCnidariaDrosophilaGenesGenetic TechniquesHeLa CellsHumansNuclear ProteinsNucleic Acid HybridizationRNA, Double-StrandedRNA, MessengerVimentinGenes, Reporter

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Recent Advances in Nanomaterials for Gene Delivery—A Review