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Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst

Developmental Cell · 2010 · Vol. 18(4) · pp. 675–685

Guoji Guo✉(National University of Singapore)Mikael Huss(Genome Institute of Singapore)Guo Qing Tong(Genome Institute of Singapore)Chaoyang Wang(Genome Institute of Singapore)Li Sun(Genome Institute of Singapore)Neil D. Clarke(Genome Institute of Singapore)Paul Robson(National University of Singapore)

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Pluripotent Stem Cells Research Single-cell and spatial transcriptomics CRISPR and Genetic EngineeringBiologyZygoteBlastocystSingle-cell analysisCell biologyBlastomereInner cell massCell fate determinationTranscription factorEmbryo

MeSH terms

AnimalsBlastocystCell CycleCell DifferentiationFemaleMaleTranscription, GeneticZygoteSignal TransductionDevelopmental BiologyTranscriptional ActivationGene Expression Regulation, DevelopmentalCell LineageGene Expression ProfilingMice

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Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells