review Open AccessTop 1% cited
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
Nature Reviews Drug Discovery · 2021 · Vol. 20(9) · pp. 689–709
Henry Jay Forman✉(University of Southern California)Hongqiao Zhang(University of Southern California)
Genomics, phytochemicals, and oxidative stressVitamin C and Antioxidants ResearchFree Radicals and AntioxidantsOxidative stressDiseaseAntioxidantMedicineClinical trialPharmacologyBioinformaticsBiologyPathologyInternal medicine
MeSH terms
Drug DevelopmentAnimalsAntioxidantsDrug Evaluation, PreclinicalHumansOxidation-ReductionSignal TransductionOxidative StressMolecular Targeted Therapy
Funding
- National Institutes of Health
Citations
2,594
FWCI
144.03
field-weighted impact
References
304
Percentile
100%
vs. same field & year
Citations per year
Cited by
The Role of Oxidative Stress in Atherosclerosis
Cells · 2022 · 447 citations
Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles
Materials · 2021 · 387 citations
Cellular Red-Ox system in health and disease: The latest update
Biomedicine & Pharmacotherapy · 2023 · 471 citations
References
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide
Biochemical Journal · 1976 · 647 citations
Superoxide Dismutase
Journal of Biological Chemistry · 1969 · 12,768 citations
Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures
Neurobiology of Aging · 2001 · 445 citations
Strategies of antioxidant defense
European Journal of Biochemistry · 1993 · 1,931 citations
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Archives of Biochemistry and Biophysics · 1993 · 2,380 citations
Targeting lipophilic cations to mitochondria
Biochimica et Biophysica Acta (BBA) - Bioenergetics · 2008 · 570 citations
Vitamin E, antioxidant and nothing more
Free Radical Biology and Medicine · 2007 · 1,427 citations
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Endocrine Reviews · 2002 · 2,213 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.